Article

Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples

2019-10-12

Abstract excerpt

<title>Abstract</title> <p>Background: Archived formalin fixed paraffin embedded (FFPE) samples are valuable clinical resources to examine clinically relevant morphology features and also to study genetic changes. However, DNA quality and quantity of FFPE samples are sub-optimal, and resulting NGS-based genetics variant detections are prone to false positives. Evaluations of wet-lab and bioinformatics approaches...

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Literature Corpus work: 02a6eed4-061a-5047-b190-9fc106e2d1e7
DOI: 10.21203/rs.2.9892/v3

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