Article

The mutational signatures of formalin fixation on the human genome

2021-03-12

Abstract excerpt

<h4>Background</h4> Formalin fixation and paraffin embedding (FFPE) of patient material remains standard practice in clinical pathology labs around the world. Clinical archives of patient material near-exclusively consist of FFPE blocks. The ability to perform high quality genome sequencing on FFPE-derived DNA would accelerate a broad spectrum of medical research. However, formalin is a recognised mutagen and seq...

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Literature Corpus work: 46f5e74d-a6e5-5990-b901-72486d05fdb2
DOI: 10.1101/2021.03.11.434918

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