Article

Gene-level heritability analysis explains the polygenic architecture of cancer

2019-04-05

Abstract excerpt

Genome-wide association studies (GWAS) have found hundreds of single nucleotide polymorphisms (SNPs) associated with increased risk of cancer. However, the amount of heritable risk explained by these variants is limited, thus leaving most of cancer heritability unexplained. Recent studies have shown that genomic regions associated with specific biological functions explain a large proportion of the heritability of...

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Literature Corpus work: 3b053524-bba8-5343-a7db-1fd3ec40349b
DOI: 10.1101/599753

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