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Population bottlenecks shape laboratory evolution of piperacillin-tazobactam resistance in <i>Klebsiella grimontii</i> and reveal a shared within-patient evolutionary trajectory

2026-06-16

Abstract excerpt

Laboratory-based experimental evolution is widely used to investigate how antimicrobial resistance (AMR) emerges and to identify resistance-associated trade-offs that could inform treatment strategies. However, there is limited understanding of how in vitro AMR evolution reflects the complexity of resistance evolution within the human host, where selective pressures, and therefore evolutionary pathways, are more...

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Literature Corpus work
fb087413-e774-5beb-b962-b754e6909004
DOI
10.64898/2026.06.15.732307
Open publication

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Population bottlenecks shape laboratory evolution of piperacillin-tazobactam resistance in <i>Klebsiella grimontii</i> and reveal a shared within-patient evolutionary trajectoryDOI 10.64898/2026.06.15.732307
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