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Article

Selective and non-selective bottlenecks as drivers of the evolution of hypermutable bacterial loci.

Molecular microbiology - 1 Mar 2020

De Ste Croix Megan, Holmes Jonathan, Wanford Joseph J, Moxon E Richard, Oggioni Marco R, Bayliss Christopher D

Abstract excerpt

Bottlenecks reduce the size of the gene pool within populations of all life forms with implications for their subsequent survival. Here, we examine the effects of bottlenecks on bacterial commensal-pathogens during transmission between, and dissemination within, hosts. By reducing genetic diversity, bottlenecks may alter individual or population-wide adaptive potential. A diverse range of hypermutable mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32185830
DOI: 10.1111/mmi.14453
PMCID: PMC7154626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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