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Article

Bypass of genetic constraints during mutator evolution to antibiotic resistance.

Proceedings. Biological sciences - 7 Apr 2015

Couce Alejandro, Rodríguez-Rojas Alexandro, Blázquez Jesús

Abstract excerpt

Genetic constraints can block many mutational pathways to optimal genotypes in real fitness landscapes, yet the extent to which this can limit evolution remains to be determined. Interestingly, mutator bacteria elevate only specific types of mutations, and therefore could be very sensitive to genetic constraints. Testing this possibility is not only clinically relevant, but can also inform about the general...

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Identifiers

PMID: 25716795
DOI: 10.1098/rspb.2014.2698
PMCID: PMC4375862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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