Bypass of genetic constraints during mutator evolution to antibiotic resistance.

doi:10.1098/rspb.2014.2698

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Article

Bypass of genetic constraints during mutator evolution to antibiotic resistance.

Proceedings. Biological sciences - 7 Apr 2015

Couce Alejandro, Rodríguez-Rojas Alexandro, Blázquez Jesús

Abstract excerpt

Genetic constraints can block many mutational pathways to optimal genotypes in real fitness landscapes, yet the extent to which this can limit evolution remains to be determined. Interestingly, mutator bacteria elevate only specific types of mutations, and therefore could be very sensitive to gen...

Topics

Alleles
Anti-Bacterial Agents
Cefotaxime
Dose-Response Relationship, Drug
Drug Resistance, Microbial
Escherichia coli
Escherichia coli Proteins
Evolution, Molecular
Models, Genetic
Mutation
Pyrophosphatases

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