Article

Fragmentation of Small-cell Lung Cancer Regulatory States in Heterotypic Microenvironments

2020-03-31

Abstract excerpt

Small-cell lung cancers derive from pulmonary neuroendocrine cells, which have stemlike properties to reprogram into other cell types upon lung injury. It is difficult to uncouple transcriptional plasticity of these transformed cells from genetic changes that evolve in primary tumors or secondary metastases. Profiling of single cells also problematic if the required sample dissociation activates injury-like signal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb04ef4c-ef7f-528f-917e-d9e247b1a168
DOI: 10.1101/2020.03.30.017210

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fragmentation of Small-cell Lung Cancer Regulatory States in Heterotypic MicroenvironmentsDOI 10.1101/2020.03.30.017210Read

Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung CancerSemantic proximity Read

Beyond Histology: A Unified Transcriptomic Atlas Defines Lung Cancer Biologic States and SubtypesSemantic proximity Read

The single-cell transcriptional landscape of lung carcinoid tumorsSemantic proximity Read

Multivalent state transitions shape the intratumoral composition of small cell lung carcinomaSemantic proximity Read

Plasticity of circulating tumor cells in small cell lung cancerSemantic proximity Read

Single-Cell RNA Sequencing in Lung Cancer: Revealing Phenotype Shaping of Stromal Cells in the Microenvironment.Semantic proximity Read

Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA SequencingSemantic proximity Read

Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived modelsSemantic proximity Read

Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformationSemantic proximity Read

Promising immunotherapeutic targets in lung cancer based on single-cell RNA sequencingSemantic proximity Read

Involvement of epithelial-mesenchymal transition genes in small cell lung cancer phenotypic plasticitySemantic proximity Read

Involvement of Epithelial–Mesenchymal Transition Genes in Small Cell Lung Cancer Phenotypic PlasticitySemantic proximity Read