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Article

Multivalent state transitions shape the intratumoral composition of small cell lung carcinoma

14 Dec 2022

Abstract excerpt

Studies to date have not resolved how diverse transcriptional programs contribute to the intratumoral heterogeneity of small cell lung carcinoma (SCLC), an aggressive tumor associated with a dismal prognosis. Here, we identify distinct and commutable transcriptional states that confer discrete functional attributes in individual SCLC tumors. We combine an integrative approach comprising the transcriptomes of...

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PMID: 36516249
DOI: 10.1126/sciadv.abp8674

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