Article

Vcam1+ Fibro-adipogenic Progenitors Mark Fatty Infiltration in Chronic Limb Threatening Ischemia

2024-07-11

Abstract excerpt

Skeletal muscle health and function is a critical determinant of clinical outcomes in patients with peripheral arterial disease (PAD). Herein, we identify fatty infiltration, the ectopic deposition of adipocytes in skeletal muscle, as a histological hallmark of end-stage PAD, also known as chronic limb threatening ischemia (CLTI). Leveraging single cell transcriptome mapping in mouse models of PAD, we identify a p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd4b633e-28ce-564c-90d9-5d2b1546d590
DOI: 10.1101/2024.07.08.602430

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vcam1+ Fibro-adipogenic Progenitors Mark Fatty Infiltration in Chronic Limb Threatening IschemiaDOI 10.1101/2024.07.08.602430Read

Intramuscular Adipose Tissue Accumulation is a Key Determinant of Limb Function in Peripheral Artery DiseaseSemantic proximity Read

Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cellsSemantic proximity Read

Single cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1 <sup>+</sup> Macrophage ActivationSemantic proximity Read

Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult miceSemantic proximity Read

Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease.Semantic proximity Read

Adipose tissue is a source of fibro-adipogenic progenitors for regenerating skeletal musclesSemantic proximity Read

Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunctionSemantic proximity Read

Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophySemantic proximity Read

Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscleSemantic proximity Read

Defining the vascular niche of human adipose tissue across metabolic statesSemantic proximity Read

Fibroadipogenic Progenitors contribute to microvascular repair during skeletal muscle regenerationSemantic proximity Read

Muscle fibro-adipogenic progenitors from a single-cell perspective: Focus on their “virtual” secretomeSemantic proximity Read