Article
Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4).
The Journal of biological chemistry - 20 Aug 2010
Ohnesorge Nils, Viemann Dorothee, Schmidt Nicole, Czymai Tobias, Spiering Désirée, Schmolke Mirco, Ludwig Stephan, Roth Johannes, Goebeler Matthias, Schmidt Marc
Abstract excerpt
The MEK5/Erk5 MAPK cascade has recently been implicated in the regulation of endothelial integrity and represents a candidate pathway mediating the beneficial effects of laminar flow, a major factor preventing vascular dysfunction and disease. Here we expressed a constitutively active mutant of MEK5 (MEK5D) to study the transcriptional and functional responses to Erk5 activation in human primary endothelial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.