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Article

Afadin Loss Uncovers an Ectopic Neurogenic Niche and Reorganizes the Adult Ventricular-Subventricular Zone

2026-07-14

Abstract excerpt

<title>Abstract</title> <p>Neural stem cells (NSCs) sustain neurogenesis within specialized niches, yet how adhesion-dependent mechanisms during development control lifelong behavior remains unclear. Here, we identify Afadin, a core adherens junction protein, as a regulator. Dorsal loss of Afadin during development drives formation of a stable, ventricular-independent ectopic germinal zone in the neocortex, popul...

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Literature Corpus work
faf69985-affb-5477-ba38-335fdcde6ad1
DOI
10.21203/rs.3.rs-10336537/v1
Open publication

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Afadin Loss Uncovers an Ectopic Neurogenic Niche and Reorganizes the Adult Ventricular-Subventricular ZoneDOI 10.21203/rs.3.rs-10336537/v1
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