Article

<i>Afadin</i> Loss Uncovers an Ectopic Neurogenic Niche and Reorganizes the Adult Ventricular-Subventricular Zone

2026-07-13

Abstract excerpt

<h4>Summary</h4> Neural stem cells (NSCs) sustain neurogenesis within specialized niches, yet how adhesion-dependent mechanisms during development control lifelong behavior remains unclear. Here, we identify Afadin , a core adherens junction protein, as a regulator. Dorsal loss of Afadin during development drives formation of a stable, ventricular-independent ectopic germinal zone in the neocortex, populated by...

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Literature Corpus work: e454cf87-1f60-5368-bf28-ff35b4b2c290
DOI: 10.64898/2026.07.13.738185

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