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Article

Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia

7 Nov 2008

Abstract excerpt

Periventricular heterotopia (PH) is a disorder characterized by neuronal nodules, ectopically positioned along the lateral ventricles of the cerebral cortex. Mutations in either of two human genes, Filamin A (FLNA) or ADP-ribosylation factor guanine exchange factor 2 (ARFGEF2), cause PH (Fox et al. in 'Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia'....

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PMID: 18996916
DOI: 10.1093/hmg/ddn377

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