Homologous Recombination Defects and Mutations in DNA Damage Response (DDR) Genes Besides BRCA1 and BRCA2 as Breast Cancer Biomarkers for PARP Inhibitors and Other DDR Targeting Therapies.

Abstract excerpt

Homologous recombination repair (HRR) is the cellular mechanism for error-free repair of double strand DNA (dsDNA) breaks. Cancer cells with mutations in both alleles of genes encoding for proteins involved in HRR, such as BRCA1 and BRCA2, have defects in the repair process. As a result, these cells repair dsDNA breaks with alternative mechanisms, such as non-homologous end joining. In breast cancers with...

Topics

• Female
• Humans
• Biomarkers, Tumor
• BRCA1 Protein
• BRCA2 Protein
• Breast Neoplasms
• DNA Damage
• Genes, BRCA2
• Homologous Recombination
• Mutation
• Poly(ADP-ribose) Polymerase Inhibitors