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The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy

1 Jan 2013

Abstract excerpt

Germ line mutations in breast cancer gene 1 (BRCA1) predispose women to breast and ovarian cancers. Although BRCA1 is involved in many important biological processes, the function of BRCA1 in homologous recombination (HR) mediated repair is considered one of the major mechanisms contributing to its tumor suppression activity, and the cause of hypersensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors when...

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PMID: 23388117
DOI: 10.1186/2045-3701-3-11

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