Article

TORC1 inhibition as an immunotherapy to reduce infections in the elderly

2017-12-11

Abstract excerpt

mTOR inhibition extends lifespan and ameliorates aging-related pathologies including declining immune function in model organisms. The objective of this Phase 2a clinical trial was to determine if low dose mTOR inhibitor therapy enhanced immune function and thereby decreased infection rates in elderly subjects. The results indicate that 6 weeks of treatment with a low dose combination of a catalytic (BEZ235) plus...

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Literature Corpus work: fab3391d-8ab1-5bc5-911f-ab9ee9412665
DOI: 10.1101/230813

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