Article

Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging

2026-02-06

Abstract excerpt

Aging is the gradual accumulation of structural and functional changes in an organism over time, including immune remodeling and a progressive increase in basal inflammation, or inflammaging. The mTOR pathway is a central driver of aging-related diseases, such as cancer, chronic inflammation and neurodegeneration; pharmacological inhibition with rapamycin is associated with reduced aged-related morbidity and incre...

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Literature Corpus work: 4e14c3b1-be54-5b2f-8f5c-6738ca5ea254
DOI: 10.64898/2026.02.04.703808

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