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A combination of the geroprotectors trametinib and rapamycin is more effective than either drug alone

2024-07-25

Abstract excerpt

Genetic suppression of activity of the insulin/IGF/mTORC1/Ras network can ameliorate the effects of ageing in animals. The network provides multiple drug targets because of its role in metabolic disease and cancer, and these are candidates for repurposing for geroprotection. For instance, inhibition of the activity of the mTORC1 complex by rapamycin can extend lifespan in multiple organisms including mice, with ea...

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Identifiers and source

Literature Corpus work
66c074c2-069d-5b3a-8d45-5ee0011acb46
DOI
10.1101/2024.07.25.605097
Open publication

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A combination of the geroprotectors trametinib and rapamycin is more effective than either drug aloneDOI 10.1101/2024.07.25.605097
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