The Role of mTOR Signaling in Controlling Mammalian Life Span: What a Fungicide Teaches Us About Longevity

Abstract excerpt

Encouraging results with rapamycin suggest that the mammalian target of rapamycin (mTOR) is a promising pharmacological target for prolongevity intervention in mammals. In theory, such an approach mimics food, energy, and/or growth factor restriction, both of which have proven to be effective in animal models but are not practical for people interested in maximizing the healthy years of their life. In a recent...

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