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The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19

1 Feb 2021

Abstract excerpt

COVID-19 disproportionately affects older people, with likelihood of severe complications and death mirroring that of other age-associated diseases. Inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) has been shown to delay or reverse many age-related phenotypes, including declining immune function. Rapamycin (sirolimus) and rapamycin derivatives are US Food and Drug Administration-approved...

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PMID: 33665645
DOI: 10.1016/s2666-7568(20)30068-4

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