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Article

A novel rapamycin analog is highly selective for mTORC1 in vivo

19 Jul 2019

Abstract excerpt

Rapamycin, an inhibitor of mechanistic Target Of Rapamycin Complex 1 (mTORC1), extends lifespan and shows strong potential for the treatment of age-related diseases. However, rapamycin exerts metabolic and immunological side effects mediated by off-target inhibition of a second mTOR-containing complex, mTOR complex 2. Here, we report the identification of DL001, a FKBP12-dependent rapamycin analog 40x more...

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PMID: 31324799
DOI: 10.1038/s41467-019-11174-0

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