Article

Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

2021-04-16

Abstract excerpt

SARS-CoV-2 infection in immunocompromised individuals is associated with prolonged virus shedding and evolution of viral variants. Rapamycin and its analogs (rapalogs, including everolimus, temsirolimus, and ridaforolimus) are FDA-approved as mTOR inhibitors for the treatment of human diseases, including cancer and autoimmunity. Rapalog use is commonly associated with increased susceptibility to infection, which h...

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Literature Corpus work: 40423237-dfa5-5868-81f5-389d6aab3c58
DOI: 10.1101/2021.04.15.440067

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