Article

Rapamycin Enhances CAR-T Control of HIV Replication and Reservoir Elimination <i>in vivo</i>

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a powerful immune therapy for various diseases. Our studies in humanized mice and non-human primates (NHPs) demonstrate that hematopoietic stem cell (HSCs) modified with anti-HIV CAR leads to lifelong engraftment and supply of functional anti-viral CAR-T cells, leading to significantly reduced viral rebound after ART withdrawal. Howev...

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Literature Corpus work: 5aaa51f3-6b03-503e-a99f-2b20c8915f69
DOI: 10.1101/2024.10.31.621350

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