Article

DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells

2024-12-22

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor, predominantly triggered by the acquisition of mutant KRAS, and is present in approximately 95% of PDAC cases. The recent introduction of KRAS inhibitors has been a source of tremendous enthusiasm; however, therapeutic resistance has emerged, and combination approaches are needed. In particular, it is important to understand how downstream signal...

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Literature Corpus work: 15c13d3e-b3cd-50a7-abfd-10093488fd46
DOI: 10.1101/2024.12.20.629199

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