Article

In Vivo Applications of Single Chain Fv (Variable Domain) (scFv) Fragments

2013-04-11

Abstract excerpt

Single chain variable domain (Fv) fragments (scFv) are powerful tools in research and clinical settings, owing to better pharmacokinetic properties compared to the parent monoclonal antibodies and the relative ease of producing them in large quantities, at low cost. Though they offer several advantages, they suffer from lower binding affinity and rapid clearance from circulation, which limits their therapeutic pot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: faab4724-c3dc-538e-a2ba-6b295582409e
DOI: 10.3390/antib2020193

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In Vivo Applications of Single Chain Fv (Variable Domain) (scFv) FragmentsDOI 10.3390/antib2020193Read

Applications of single-chain variable fragment antibodies in therapeutics and diagnosticsSemantic proximity Read

Generic Approach for the Generation of Stable Humanized Single-chain Fv Fragments from Rabbit Monoclonal AntibodiesSemantic proximity Read

Antibody Production Techniques and Antibody Types: Evolution, Methodologies, and ApplicationsSemantic proximity Read

Monoclonal Antibody Engineering and Design to Modulate FcRn Activities: A Comprehensive ReviewSemantic proximity Read

Solubility, Stability, and Avidity of Recombinant Antibody Fragments Expressed in MicroorganismsSemantic proximity Read

Development of a Functional Antibody by Using a Green Fluorescent Protein Frame as the TemplateSemantic proximity Read

Single domain antibody: Development and application in biotechnology and biopharmaSemantic proximity Read

Antibody Structure and Function: The Basis for Engineering TherapeuticsSemantic proximity Read

Next-generation flexible formats of VNAR domains expand the drug platform's utility and developabilitySemantic proximity Read

Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discoverySemantic proximity Read

Variable fragments of heavy chain antibodies (VHHs): a new magic bullet molecule of medicine?Semantic proximity Read

Optimization and modification of anti-rhTNF-α single chain variable fragment antibody: effective in vitro affinity maturation and functional expression of chimeric Fab.Semantic proximity Read