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Single domain antibody: Development and application in biotechnology and biopharma

21 Aug 2024

Abstract excerpt

Heavy-chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains-only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb), or nanobody (Nb). These functional HCAbs, serendipitous discovered about three decades ago, are exclusively found in camelids, comprising dromedaries, camels,...

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PMID: 39166870
DOI: 10.1111/imr.13381

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