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Article

Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability

31 Oct 2018

Abstract excerpt

Therapeutic mAbs have delivered several blockbuster drugs in oncology and autoimmune inflammatory disease. Revenue for mAbs continues to rise, even in the face of competition from a growing portfolio of biosimilars. Despite this success, there are still limitations associated with the use of mAbs as therapeutic molecules. With a molecular mass of 150 kDa, a two-chain structure and complex glycosylation these...

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PMID: 30381336
DOI: 10.1042/bst20180177

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