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Monoclonal Antibody Engineering and Design to Modulate FcRn Activities: A Comprehensive Review

24 Aug 2022

Abstract excerpt

Understanding the biological mechanisms underlying the pH-dependent nature of FcRn binding, as well as the various factors influencing the affinity to FcRn, was concurrent with the arrival of the first recombinant IgG monoclonal antibodies (mAbs) and IgG Fc-fusion proteins in clinical practice. IgG Fc-FcRn became a central subject of interest for the development of these drugs for the comfort of patients and good...

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PMID: 36077002
DOI: 10.3390/ijms23179604

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