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Article

Orthogonal and multiplexable genetic perturbations with an engineered prime editor and a diverse RNA array.

Nature communications - 30 Dec 2024

Yuan Qichen, Zeng Hongzhi, Daniel Tyler C, Liu Qingzhuo, Yang Yongjie, Osikpa Emmanuel C, Yang Qiaochu, Peddi Advaith, Abramson Liliana M, Zhang Boyang, Xu Yong, Gao Xue

Abstract excerpt

Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime...

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Identifiers

PMID: 39737993
DOI: 10.1038/s41467-024-55134-9
PMCID: PMC11685949

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