Back to search

Article

Myeloid-specific KDM6B inhibition sensitizes Glioblastoma to PD1 blockade

2022-11-29

Abstract excerpt

Glioblastoma (GBM) tumors are enriched in immune-suppressive myeloid cells and are refractory to immune checkpoint therapy (ICT). Targeting epigenetic pathways to reprogram the functional phenotype of immune-suppressive myeloid cells to overcome resistance to ICT remains unexplored. Single-cell and spatial transcriptomic analyses of human GBM tumors demonstrated high expression of an epigenetic enzyme - histone 3...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
081f2fcf-5da0-5b3c-bb89-72dd77f2c538
DOI
10.1101/2022.11.28.518243
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Myeloid-specific KDM6B inhibition sensitizes Glioblastoma to PD1 blockadeDOI 10.1101/2022.11.28.518243
Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade.Semantic proximity
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights tumor-promoting macrophage cells in GlioblastomaSemantic proximity
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in GlioblastomaSemantic proximity
Targeting lysine demethylase 6B ameliorates ASXL1 truncation–mediated myeloid malignancies in preclinical modelsSemantic proximity
m6A RNA methylation: a pivotal regulator of tumor immunity and a promising target for cancer immunotherapySemantic proximity
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in GlioblastomaSemantic proximity
N6-Methyladenosine Regulator-Mediated Immue Patterns and Tumor Microenvironment Infiltration Characterization in GlioblastomaSemantic proximity
Targeting glioma stem‐like cell survival and chemoresistance through inhibition of lysine‐specific histone demethylase KDM 2BSemantic proximity
Identification of m6A methyltransferase-related WTAP and ZC3H13 predicts immune infiltrates in glioblastomaSemantic proximity
m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma.Semantic proximity
Multi-omics analyses of CD276 in pan-cancer reveals its clinical prognostic value in glioblastoma and other major cancer typesSemantic proximity
DNA methylation regulator-mediated modification patterns and tumor microenvironment characterization in gliomaSemantic proximity
Select a neighboring publication to make it the new centre.