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Elevated Serum IL-6 as a Negative Prognostic Biomarker in Glioblastoma: Integrating Bioinformatics and Clinical Validation

31 Dec 2024

Abstract excerpt

Background: Glioblastoma multiforme (GBM) is the most lethal type of primary brain tumor, necessitating the discovery of reliable serum prognostic biomarkers.This study aimed to investigate the prognostic value of serum Interleukin-6 (IL-6) in GBM patients.Methods: Bioinformatics analysis via gene set enrichment analysis was conducted on The Cancer Genome Atlas RNA-seq data to explore the pathways enriched in...

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PMID: 39781345
DOI: 10.7150/jca.104759

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