Article

In Silico proteomic analysis of mutations in PmrAB, PhoPQ, and mgrB Genes: Chromosomal-Mediated Colistin Resistance

2025-04-22

Abstract excerpt

The emergence of colistin resistance in Gram-negative bacteria poses a significant threat to public health, particularly due to its association with mutations in regulatory genes such as pmrA, pmrB, phoP, phoQ, and mgrB. This study aimed to evaluate the structural and functional consequences of mutations in these genes through in silico approaches. Predictive tools including PredictSNP, PolyPhen, SIFT, SNAP, Dyna...

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Literature Corpus work: fa69b939-828c-551d-89de-3a0615686387
DOI: 10.22541/au.174534321.17656734/v1

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