Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of PmrB mutations on clinical Klebsiella pneumoniae with variable colistin-susceptibilities: Structural insights and potent therapeutic solutions.

Chemical biology & drug design - 1 Jan 2024

Basu Soumya, Veeraraghavan Balaji, Anbarasu Anand

Abstract excerpt

Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections continue to impose high morbidity threats to hospitalized patients worldwide, limiting therapeutic options to last-resort antibiotics like colistin. However, the dynamic genomic landscape of colistin-resistant K. pneumoniae (COLR-Kp) invoked ardent exploration of underlying molecular signatures for therapeutic propositions/designs. We unveiled the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colistin

Share to Drug Resistance, Bacterial

Share to Klebsiella Infections

Share to Klebsiella pneumoniae

Share to Microbial Sensitivity Tests

Share to Mutant Proteins

Source

Identifiers

PMID: 37875387
DOI: 10.1111/cbdd.14381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of PmrB mutations on clinical Klebsiella pneumoniae with variable colistin-susceptibilities: Structural insights and potent therapeutic solutions.PMID 37875387Read ↗

Investigating the role of PmrB mutation on Colistin antibiotics drug resistance in Klebsiella Pneumoniae.Semantic proximity Read ↗

A phylogenomic approach for the analysis of colistin resistance-associated genes in Klebsiella pneumoniae, its mutational diversity and implications for phenotypic resistance.Semantic proximity Read ↗

In vivo Emergence of Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Premature Termination of the mgrB Gene RegulatorSemantic proximity Read ↗

Epidemiological characterization of chromosome-mediated colistin resistance in hypervirulent carbapenem-resistant Klebsiella pneumoniae.Semantic proximity Read ↗

A comprehensive analysis of the mutational landscape determining polymyxin resistance in Klebsiella pneumoniae.Semantic proximity Read ↗

MgrB mutations causing colistin resistance in ST11 and ST15 Klebsiella pneumoniaes in a tertiary teaching hospital in ChinaSemantic proximity Read ↗

Identification of a novel mutation involved in colistin resistance in Klebsiella pneumoniae through Next-Generation Sequencing (NGS) based approaches.Semantic proximity Read ↗

Characterization and targeting of deleterious mutations in Carbapenemase-producing Klebsiella pneumoniae: insights from variant calling, Computer-aided drug design, and DFT analysis.Semantic proximity Read ↗

Emergence of colistin-resistant hypervirulent <i>Klebsiella pneumoniae</i> (CoR-HvKp) in ChinaSemantic proximity Read ↗

Molecular characterization of colistin resistance in carbapenem-resistant Klebsiella pneumoniae from a tertiary hospital in ChinaSemantic proximity Read ↗

The mecillinam resistome in Klebsiella pneumoniae: how resistance to a one-target β-lactam triggers a diversity of responses.Semantic proximity Read ↗

MgrB Mutations and Altered Cell Permeability in Colistin Resistance in Klebsiella pneumoniae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.