Article
Structure of the Acinetobacter baumannii PmrA receiver domain and insights into clinical mutants affecting DNA binding and promoting colistin resistance.
Journal of biochemistry - 7 Jan 2022
Palethorpe Samantha, Milton Morgan E, Pesci Everett C, Cavanagh John
Abstract excerpt
Acinetobacter baumannii is an insidious emerging nosocomial pathogen that has developed resistance to all available antimicrobials, including the last resort antibiotic, colistin. Colistin resistance often occurs due to mutations in the PmrAB two-component regulatory system. To better understand the regulatory mechanisms contributing to colistin resistance, we have biochemically characterized the A. baumannii...
Topics
- Acinetobacter baumannii
- Amino Acid Motifs
- Bacterial Proteins
- Colistin
- Crystallography, X-Ray
- DNA, Bacterial
- Drug Resistance, Bacterial
- Mutation
- Protein Domains