Article
Retained colistin susceptibility in clinical Acinetobacter baumannii isolates with multiple mutations in pmrCAB and lpxACD operons.
Frontiers in cellular and infection microbiology - 1 Jan 2023
Zafer Mai M, Hussein Amira F A, Al-Agamy Mohamed H, Radwan Hesham H, Hamed Samira M
Abstract excerpt
The progressive increase in the resistance rates to first- and second-line antibiotics has forced the reuse of colistin as last-line treatment for Acinetobacter baumannii infections, but the emergence of colistin-resistant strains is not uncommon. This has been long linked to acquired chromosomal mutations in the operons pmrCAB and lpxACD. Hence, such mutations are routinely screened in colistin-resistant strains...
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