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Article

Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 Oct 2017

Phan Minh-Duy, Nhu Nguyen Thi Khanh, Achard Maud E S, Forde Brian M, Hong Kar Wai, Chong Teik Min, Yin Wai-Fong, Chan Kok-Gan, West Nicholas P, Walker Mark J, Paterson David L, Beatson Scott A, Schembri Mark A

Abstract excerpt

Objectives: Polymyxins remain one of the last-resort drugs to treat infections caused by MDR Gram-negative pathogens. Here, we determined the mechanisms by which chromosomally encoded resistance to colistin and polymyxin B can arise in the MDR uropathogenic Escherichia coli ST131 reference strain EC958. Methods: Two complementary approaches, saturated transposon mutagenesis and spontaneous mutation induction with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29091192
DOI: 10.1093/jac/dkx204

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