Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A comprehensive analysis of the mutational landscape determining polymyxin resistance in Klebsiella pneumoniae.

The Journal of antimicrobial chemotherapy - 19 Jan 2026

Dwibedy Sambit Kumar, Padhy Indira, Mohapatra Saswat Sourav

Abstract excerpt

BACKGROUND: Klebsiella pneumoniae poses a critical global health threat due to its increasing resistance to polymyxin, the last-line antibiotic. Outer membrane remodelling, mediated by various two-component systems (TCS), is primarily involved in the development of polymyxin resistance (PolR). This study conducted an in-depth analysis of mutations within TCS-associated genes that contribute to PolR in K....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Klebsiella pneumoniae

Share to Mutation

Source

Identifiers

PMID: 41549668
DOI: 10.1093/jac/dkaf503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comprehensive analysis of the mutational landscape determining polymyxin resistance in Klebsiella pneumoniae.PMID 41549668Read ↗

Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae.Semantic proximity Read ↗

Multifactorial Chromosomal Variants Regulate Polymyxin Resistance in Extensively Drug-Resistant <i>Klebsiella pneumoniae</i>Semantic proximity Read ↗

Insertion sequence mediating mrgB disruption is the major mechanism of polymyxin resistance in carbapenem-resistant Klebsiella pneumoniae isolates from ChinaSemantic proximity Read ↗

Emergence of Polymyxin Resistance in Clinical Klebsiella pneumoniae Through Diverse Genetic Adaptations: A Genomic, Retrospective Cohort StudySemantic proximity Read ↗

Novel polymyxin-resistant Klebsiella pneumoniae with ten resistance determinants and associated mutations drive localized outbreaks.Semantic proximity Read ↗

Proteomic Changes of Klebsiella pneumoniae in Response to Colistin Treatment and crrB Mutation-Mediated Colistin Resistance.Semantic proximity Read ↗

Clinical relevance, mechanisms, and evolution of polymyxin B heteroresistance carbapenem-resistant Klebsiella pneumoniae: A genomic, retrospective cohort studySemantic proximity Read ↗

A Review of Resistance to Polymyxins and Evolving Mobile Colistin Resistance Gene (mcr) among Pathogens of Clinical SignificanceSemantic proximity Read ↗

Molecular analysis of polymyxin B resistance in clinical carbapenem-resistant Klebsiella pneumoniae isolates from a large tertiary care teaching hospital in Southwest China.Semantic proximity Read ↗

Molecular Mechanism of Polymyxin Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli Isolates from Henan Province, China: A Multicenter StudySemantic proximity Read ↗

Impact of PmrB mutations on clinical Klebsiella pneumoniae with variable colistin-susceptibilities: Structural insights and potent therapeutic solutions.Semantic proximity Read ↗

Molecular and epidemiological surveillance of polymyxin-resistant Klebsiella pneumoniae strains isolated from Brazil with multiple mgrB gene mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.