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Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

26 Dec 2022

Abstract excerpt

monocytes in patients with mild and moderate COVID-19 during the acute phase of infection and in healthy individuals. Monocytes from COVID-19 patients display altered expression of cell surface receptors and a dysfunctional metabolic profile that distinguish them from healthy monocytes. Secondary pathogen sensing ex vivo leads to defects in pro-inflammatory cytokine and type-I IFN production in moderate COVID-19...

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PMID: 36572683
DOI: 10.1038/s41467-022-35638-y

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