Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study.

doi:10.7554/eLife.67569

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Article

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study.

eLife - 2 Mar 2021

Fallerini Chiara, Daga Sergio, Mantovani Stefania, Benetti Elisa, Picchiotti Nicola, Francisci Daniela, Paciosi Francesco, Schiaroli Elisabetta, Baldassarri Margherita, Fava Francesca, Palmieri Maria, Ludovisi Serena, Castelli Francesco, Quiros-Roldan Eugenia, Vaghi Massimo, Rusconi Stefano, Siano Matteo, Bandini Maria, Spiga Ottavia, Capitani Katia, Furini Simone, Mari Francesca, Renieri Alessandra, Mondelli Mario U, Frullanti Elisa

Abstract excerpt

Background: Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients. Methods: This is a nested case-control study in which we compared male participants with extreme phenotype...

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PMID: 33650967
DOI: 10.7554/eLife.67569
PMCID: PMC7987337

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