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Article

Genetic Architectures of Myeloid Dysregulation in Severe COVID-19.

Viruses - 26 May 2026

Kashatnikova Darya A, Gracheva Alesya S, Kuzovlev Artem N, Salnikova Lyubov E

Abstract excerpt

Background: Dysregulated myeloid responses are central to severe COVID-19, but the contribution of host genetics to this "emergency myelopoiesis" is poorly understood. Methods: We performed whole-exome sequencing in 77 hospitalized COVID-19 patients to analyze the impact of the cumulative burden of rare, high-impact variants (qualifying variants, QVs) in hemopoietic and inflammatory gene sets on longitudinal...

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Identifiers

PMID: 42357614
DOI: 10.3390/v18060604
PMCID: PMC13307768

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