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Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS

23 May 2023

Abstract excerpt

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular switches in regulating key cellular functions. Their dysregulation is a therapeutic target for tumors, neurodegeneration, cardiomyopathies, and infection. However, small GTPases have been historically recognized as “undruggable”. Targeting KRAS, one of the most frequently mutated oncogenes, has only come into reality in the...

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PMID: 37221195
DOI: 10.1038/s41392-023-01441-4

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