Article
Functional and biological heterogeneity of KRASQ61 mutations.
Science signaling - 9 Aug 2022
Huynh Minh V, Hobbs G Aaron, Schaefer Antje, Pierobon Mariaelena, Carey Leiah M, Diehl J Nathaniel, DeLiberty Jonathan M, Thurman Ryan D, Cooke Adelaide R, Goodwin Craig M, Cook Joshua H, Lin Lin, Waters Andrew M, Rashid Naim U, Petricoin Emanuel F, Campbell Sharon L, Haigis Kevin M, Simeone Diane M, Lyssiotis Costas A, Cox Adrienne D, Der Channing J
Abstract excerpt
Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS-Gly12, Gly13, and Gln61 (commonly known as G12, G13, and Q61, respectively)-occur differentially among the three RAS isoforms. Q61 mutations in KRAS are infrequent and differ markedly in occurrence. Q61H is the predominant mutant (at 57%), followed by Q61R/L/K (collectively 40%), and Q61P and Q61E are the rarest (2 and 1%,...
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