Article
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
Cancer discovery - 1 Jan 2020
Hobbs G Aaron, Baker Nicole M, Miermont Anne M, Thurman Ryan D, Pierobon Mariaelena, Tran Timothy H, Anderson Andrew O, Waters Andrew M, Diehl J Nathaniel, Papke Bjoern, Hodge Richard G, Klomp Jennifer E, Goodwin Craig M, DeLiberty Jonathan M, Wang Junning, Ng Raymond W S, Gautam Prson, Bryant Kirsten L, Esposito Dominic, Campbell Sharon L, Petricoin Emanuel F, Simanshu Dhirendra K, Aguirre Andrew J, Wolpin Brian M, Wennerberg Krister, Rudloff Udo, Cox Adrienne D, Der Channing J
Abstract excerpt
Allele-specific signaling by different KRAS alleles remains poorly understood. The KRAS G12R mutation displays uneven prevalence among cancers that harbor the highest occurrence of KRAS mutations: It is rare (∼1%) in lung and colorectal cancers, yet relatively common (∼20%) in pancreatic ductal adenocarcinoma (PDAC), suggesting context-specific properties. We evaluated whether KRASG12R is functionally distinct...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.