Back to search

Article

Therapeutic Strategies for Anti-TNF Non-Responsive IBD Patients

2024-12-31

Abstract excerpt

<title>Abstract</title> <p>To investigate genetic markers and pathways influencing anti-TNF therapy response in inflammatory bowel disease (IBD), we analyzed bulk RNA-seq data (GSE186963) from responders and non-responders, identifying 619 significantly altered genes. Key findings included upregulated genes like LCN2, associated with inflammation and tissue injury, and downregulated genes such as CTLA4, an immune...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
03ed4e9c-b665-5aeb-9593-9b4dbf60fc68
DOI
10.21203/rs.3.rs-5734261/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Therapeutic Strategies for Anti-TNF Non-Responsive IBD PatientsDOI 10.21203/rs.3.rs-5734261/v1
The Clinical Response of Upadacitinib and Risankizumab is Associated with Reduced Inflammatory Bowel Disease Anti-TNFα Inadequate Response MechanismsSemantic proximity
Large-scale transcriptomic meta-analysis identifies novel therapeutic targets for ulcerative colitisSemantic proximity
Genetic association of primary non-response to Anti-TNFα therapy in patients with Inflammatory Bowel DiseaseSemantic proximity
Integrative Bioinformatics Analysis of Single Cell RNA-Sequencing Data Reveals Key Regulatory Genes and Therapeutic Targets in Inflammatory Bowel DiseaseSemantic proximity
Precision therapy for ulcerative colitis: insights from mitochondrial dysfunction interacting with the immune microenvironmentSemantic proximity
Mitochondrial dysfunction: unraveling the elusive biology behind anti-TNF response during ulcerative colitisSemantic proximity
Integrative multi-omic analyses identify candidate targets for celiac disease involving tissue-specific regulationSemantic proximity
Integrative multi-omic analyses identify candidate targets for celiac disease involving tissue-specific regulationSemantic proximity
Novel Transcriptomic Signatures in Fibrostenotic Crohn’s Disease: Dysregulated Pathways, Promising Biomarkers, and Putative Therapeutic TargetsSemantic proximity
Causal Insights Into Crohn's Disease: The Role of Oxidative Stress and Genetic Variants.Semantic proximity
Identification of differentially expressed genes associated with ferroptosis in ulcerative colitisSemantic proximity
Integrated Gene Expression Profiling Analysis Reveals Probable Molecular Mechanism and Candidate Biomarker in Anti-TNFα Non-Response IBD PatientsSemantic proximity
Select a neighboring publication to make it the new centre.