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Atlas of HIV cis-regulatory elements reveals extensive transcriptional variation across clades, isolates, and within individuals

2026-04-06

Abstract excerpt

<h4>Summary</h4> Human immunodeficiency virus (HIV) replication, persistence, and reactivation depend on transcription from integrated proviruses. Despite extensive sequence variation, how viral genetic diversity influences transcriptional regulation remains poorly understood. Here, we generate a functional regulatory atlas of HIV-1 and HIV-2 by combining tiling and saturation mutagenesis massively parallel repor...

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Literature Corpus work
6eca555b-1e20-5303-b0f5-3fa205148daf
DOI
10.64898/2026.04.03.716403
Open publication

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Atlas of HIV cis-regulatory elements reveals extensive transcriptional variation across clades, isolates, and within individualsDOI 10.64898/2026.04.03.716403
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