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Article

Genome-wide construction of a series of designed segmental aneuploids in Saccharomyces cerevisiae.

Scientific reports - 30 Jul 2015

Natesuntorn Waranya, Iwami Kotaro, Matsubara Yuki, Sasano Yu, Sugiyama Minetaka, Kaneko Yoshinobu, Harashima Satoshi

Abstract excerpt

Segmental aneuploidy can play an important role in environmental adaptation. However, study of segmental aneuploids is severely hampered by the difficulty of creating them in a designed fashion. Here, we describe a PCR-mediated chromosome duplication (PCDup) technology that enables the generation of segmental aneuploidy at any desired chromosomal region in Saccharomyces cerevisiae. We constructed multiple strains...

Topics

Acids
Aneuploidy
Chromosome Duplication
Chromosomes
Ethanol
Gene Dosage
Genome, Fungal
Karyotyping
Phenotype
Plasmids
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Temperature

Source

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Identifiers

PMID: 26224198
DOI: 10.1038/srep12510
PMCID: PMC4519793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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