Article
Genome-wide consequences of deleting any single gene.
Molecular cell - 21 Nov 2013
Teng Xinchen, Dayhoff-Brannigan Margaret, Cheng Wen-Chih, Gilbert Catherine E, Sing Cierra N, Diny Nicola L, Wheelan Sarah J, Dunham Maitreya J, Boeke Jef D, Pineda Fernando J, Hardwick J Marie
Abstract excerpt
Loss or duplication of chromosome segments can lead to further genomic changes associated with cancer. However, it is not known whether only a select subset of genes is responsible for driving further changes. To determine whether perturbation of any given gene in a genome suffices to drive subsequent genetic changes, we analyzed the yeast knockout collection for secondary mutations of functional consequence....
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