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Article

A catalog of neutral and deleterious polymorphism in yeast.

PLoS genetics - 29 Aug 2008

Doniger Scott W, Kim Hyun Seok, Swain Devjanee, Corcuera Daniella, Williams Morgan, Yang Shiaw-Pyng, Fay Justin C

Abstract excerpt

The abundance and identity of functional variation segregating in natural populations is paramount to dissecting the molecular basis of quantitative traits as well as human genetic diseases. Genome sequencing of multiple organisms of the same species provides an efficient means of cataloging rearrangements, insertion, or deletion polymorphisms (InDels) and single-nucleotide polymorphisms (SNPs). While inbreeding...

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PMID: 18769710
DOI: 10.1371/journal.pgen.1000183
PMCID: PMC2515631

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