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Low avidity T cells drive endogenous tumor immunity in mice and humans

2024-04-04

Abstract excerpt

<title>Abstract</title> <p>CD8 T cells which recognize neoepitopes are central to immune control of cancers. T cells, through T cell receptors, recognize neoepitope peptide-MHC I on cancer cells. The strength (or avidity) of the T cell receptor- peptide-MHCI interaction is a critical variable in immune control of cancers in vivo. Here, analyzing neoepitope-specific CD8 cells of distinct avidities to validated neo...

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Literature Corpus work
c6e0f3fa-da44-5e73-a3c1-e7ff630259e3
DOI
10.21203/rs.3.rs-3903457/v1
Open publication

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Low avidity T cells drive endogenous tumor immunity in mice and humansDOI 10.21203/rs.3.rs-3903457/v1
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