Article

Tregs constrain CD8 <sup>+</sup> T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

2023-02-01

Abstract excerpt

Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves antitumor immune responses in preclinical studies, clinical development has been hampered by on-target, off-tumor toxicity. Here, we report the development of a tumor-anchored α4-1BB agonist (α4-1BB-LAIR), which consists of an α4-1BB antibody fused to the collagen binding protein LAIR. While combination treatment with an an...

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Identifiers and source

Literature Corpus work: 4470fd54-495e-5f27-88bc-16e81713dc58
DOI: 10.1101/2023.01.30.526116

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